Modelado matemático de ingestas de alimento e infusión de insulina en un paciente con diabetes tipo 1 en lazo cerrado
DOI:
https://doi.org/10.4995/riai.2019.11161Palabras clave:
Diabetes Tipo 1, Modelo Matemático Dinámica Glucosa - Insulina, Regulación de Insulina en Lazo CerradoResumen
La diabetes tipo 1 es una afección en la cual el páncreas pierde su capacidad de producir suficiente insulina, incrementando significativamente la concentración de glucosa en la sangre. En el presente trabajo se presenta el diseño de un modelo matemático de las dinámicas glucosa-insulina de un paciente con diabetes tipo 1, el cual contempla el aporte a la concentración de glucosa en la sangre por parte de la ingesta de carbohidratos, grasas y proteínas. El modelo incluye las dinámicas de absorción de 5 tipos de insulina, diferentes métodos de administración de la misma, y la variación de la sensibilidad a la insulina durante el día. Se integró el modelo a un algoritmo de regulación de insulina en lazo cerrado, con el fin de evaluar el desempeño del modelo y la eficacia de los tratamientos en lazo cerrado, en comparación con las terapias en lazo abierto. Los resultados muestran la respuesta del modelo ante distintas situaciones de un paciente real, y pruebas de funcionamiento del controlador.Descargas
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